Dopamin D2 retseptori

Dopamin D₂ retseptori, shuningdek, D₂R deb ham ataluvchi protein. Tarkibida insondagi DRD2 geni orqali enkodlanadigan oqsil mavjud. Paul Greengard labalatoriyasida olib borgan qator izlanishlaridan soʻng, organizmdagi antipsixologik preparatlar kuchli taʼsir koʻrsatadigan qism dopamin retseptorlari ekanligini aytgan. Dopamin D2 retseptorlari koʻpchilik antipsikotik dorilar uchun asosiy retseptor hisoblanadi. Atipik antipsixot risperidon bilan kompleks shaklda DRD2 ning tuzilishi aniqlangan^[1]^[2].

Manbalar

↑ "Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone". Nature 555 (7695): 269–273. March 2018. doi:10.1038/nature25758. PMID 29466326. PMC 5843546. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5843546.
↑ „NIMH » Molecular Secrets Revealed: Antipsychotic Docked in its Receptor“ (en). www.nimh.nih.gov (2018-yil 29-yanvar). Qaraldi: 2018-yil 26-noyabr.

[pmid29466326-1] "Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone". Nature 555 (7695): 269–273. March 2018. doi:10.1038/nature25758. PMID 29466326. PMC 5843546. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5843546.

[2] „NIMH » Molecular Secrets Revealed: Antipsychotic Docked in its Receptor“ (en). www.nimh.nih.gov (2018-yil 29-yanvar). Qaraldi: 2018-yil 26-noyabr.

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